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Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.5% | 575.51 | 100 MG
Supplier: Medchemexpress LLC HY14792B100MG
Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist, demonstrating potent anti-proliferative activities both in vitro and in vivo, with an IC50 of 0.8 nM for growth inhibition. Its biological activity is dependent on PPARγ.
- Upregulates the cell cycle kinase inhibitor p21WAF1/CIP1
- Activates PPARγ:RXRα-dependent transcription at 10 nM
- Specifically activates PPARγ, unlike PPARα or PPARδ
- Exhibits a low EC50 of 1 nM for activating PPARγ in DRO cells
- Potently inhibits growth with an IC50 of 0.8 nM
- Shows additive antiproliferative activity when combined with paclitaxel
- Inhibits tumor growth in a dose-responsive manner in vivo, including established DRO and ARO tumors
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