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AdipoGen Inosine
Supplier: AdipoGen AGCR13554M100
Chemical. CAS 58-63-9. Formula C10H12N4O5. MW 268.2. Inosine, an intermediate in purine metabolism, consists of hypoxanthine and ribose. It is an inert purine nucleoside formed by breakdown of adenosine deamination, known as A-to-I editing that occurs in tRNA and mRNA or also is generated by the action of 5-nucleotidase on inosine monophosphate IMP. Inosine has neuroprotective, cardioprotective, immunomodulatory, anti-tumor and anti-inflammatory effects in different experimental models. Inosine functions are mediated in receptor-dependent or-independent manners. The receptor-mediated function of inosine is thought to be related to adenosine receptor family members including A1, A2A, A2B, and A3 G-protein coupled receptors. It is an agonist for adenosine A1 A1R and A2A A2AR receptors. Inosine is released from brown adipocytes BAs upon stress. Inosine activates purinergic P1 receptors, triggering BA activation and white adipocyte browning.
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