Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Cell Lines and Blood Products
  4. Cell Lines and Cell Cultures
  5. General Cell Lines and Cell Cultures
  6. SCC147

MilliporeSigma™ TPC-1 Human Papillary Thyroid Carcinoma Cell Line

Catalog No. SCC147 Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
≥ 1 x 10^6 cells/vial
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
SCC147 ≥ 1 x 10^6 cells/vial
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. SCC147 Supplier MilliporeSigma™ Supplier No. SCC147
Only null left
Add to Cart
Add to Cart

Description

TPC-1 is a widely published and well-characterized cell line isolated from a papillary thyroid carcinoma of a female patient

  • The genome of TPC-1 contains the RET/PTC1 rearrangement found in approximately 20% of sporadic papillary carcinomas in adults
  • TPC-1 harbors a silent polymorphism in H-RAS, and is wild-type for sequences of BRAF, CNBB1, EGFR, K-RAS, RAF-1, PI3K, and TRHB
  • TPC-1 cells produce thyroglobulin (Tg) as well as expressing the thyroid differentiation marker PAX8 and the tumor progression factor podoplanin
  • TPC-1 has been utilized as an in vitro model for human cytomegalovirus latency, a potential contributor for certain human cancers
  • The TPC-1 cell line is thus an excellent system for investigating mechanisms of thyroid carcinogenesis
TRUSTED_SUSTAINABILITY

Specifications

Content And Storage Store in liquid nitrogen
Format Vial
Quantity ≥ 1 x 10^6 cells/vial
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.