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ACROBiosystems Mouse ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (IT6-M52W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 (ITGAV) & Gly 22 - Pro 708 (ITGB6) (Accession # P43406-1 (ITGAV) & Q9Z0T9-1 (ITGB6)).
Supplier: ACROBiosystems IT6M52W9100UG
Integrin alpha V β 6 is a heterodimer of β-6 associating with alpha-V. Integrin alpha-V β-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V β-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V β-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-β latency‑associated peptide (LAP) and activates TGF-β 1 or TGF-β 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
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