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ABclonal Technology Integrin alpha-6/ITGA6
Supplier: ABclonal Technology A26707100UL
The gene encodes a member of the integrin alpha chain family of proteins Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family The alpha 6 beta 4 integrin may promote tumorigenesis while the alpha 6 beta 1 integrin may negatively regulate erbB2 HER2 signaling Alternative splicing results in multiple transcript variants
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