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ACROBiosystems Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free (IT5-R52E3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 | Leu 25 - Asn 719 (Accession # NP_001385621.1 | NP_671480.2).
Supplier: ACROBiosystems IT5R52E3100UG
Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
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