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STEMCELL Technologies Mouse Recombinant IL-11, Size: 1000 µg
Supplier: STEMCELL Technologies 78026.3
Use interleukin 11 (IL-11) together with IL-3, IL-6, and stem cell factor to induce the expansion and proliferation of colony-forming cells in vitro (Peters et al. Blood, 1996). In combination with IL-3, IL-11 significantly enhances the growth of megakaryocytic colonies in vitro, suggesting its role in augmenting mouse megakaryopoiesis (Yonemura et al. Exp Hematol, 1992). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. Expressed in a wide range of normal adult mouse tissues, IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs (Cameron et al. Cytokine Growth Factor Rev, 2015). Mouse recombinant IL-11 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 250 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Adipogenic inhibitory factor, AGIF, Interleukin-11, Oprelvekin.
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