STEMCELL Technologies Human Recombinant IL-13, Size: 1000 µg

Supplier:  STEMCELL Technologies 78029.3

Use interleukin 13 (IL-13) to promote B cell proliferation, induce class switching to IgG4 and IgE, and recruit and activate IgE-producing B cells (Hershey. J Allergy Clin Immunol, 2003). IL-13 is a cytokine important in type 2 immune responses and is expressed by T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) (Pulendran & Artis. Science, 2012). It binds a receptor composed of IL-4Ra and IL-13Ra1 or IL-13Ra2 (Wynn. Annu Rev Immunol, 2003) and is expressed on a wide range of cells.. Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways. In vivo, IL-13 has a role in resistance to extracellular helminth parasites, as well as in airway hyperresponsiveness, allergic inflammation, tissue remodeling, tumor cell growth, and fibrosis (Wynn. Nat Rev Immunol, 2015). Human recombinant IL-13 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 5 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Interleukin-13, NC30.

Catalog No. 50-226-9637