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AdipoGen iODN (inhibitory ODN) 2088 Endotoxin-free (sterile)
Supplier: AdipoGen IAX200050M001
iODN (inhibitory ODN) 2088 Endotoxin-free (sterile), AdipoGen Life Sciences. Chemical. MW: 4,887g/mol. In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11-15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation.
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