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Cayman Chemical IonIzable LIpId 4 50mg
Supplier: Cayman Chemical 4049650 MG
An ionizable cationic lipid (pKa = 6.1) and hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5; CALNPs containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing; LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model
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