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Apexbio Technology LLC IOX2(Glycine) 931398-72-0 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A41895.1

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IOX2(Glycine) (CAS 931398-72-0) is a selective inhibitor targeting hypoxia-inducible factor-prolyl hydroxylase-2 (PHD2) a key enzyme regulating oxygen sensing by mediating hydroxylation of HIF-1 IOX2 exhibits high target specificity demonstrating an IC50 of approximately 21 nM against PHD2 in vitro and negligible inhibition (over 100-fold selectivity) toward related enzymes such as JMJD2 isoforms and the 2OG-oxygenase FIH In RCC4 cells IOX2 at 50 M effectively suppresses HIF-1 hydroxylation highlighting its utility as a pharmacological probe in studying hypoxia signaling pathways and oxygen-dependent cellular responses

Catalog No. 50-000-62368


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