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Medchemexpress LLC Ipatasertib | 1001264-89-6 | 458.00 | 200 MG
Supplier: Medchemexpress LLC 200MGHY15186
Ipatasertib (GDC-0068) is an orally active, highly selective, and ATP-competitive pan-Akt inhibitor. It activates FoxO3a and NF-κB through Akt inhibition, leading to p53-independent activation of PUMA, and induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.
- Orally active and highly selective pan-Akt inhibitor
- ATP-competitive inhibition of Akt1, Akt2, and Akt3
- Synchronously activates FoxO3a and NF-κB
- Leads to p53-independent activation of PUMA
- Induces apoptosis in cancer cells
- Inhibits tumor growth in xenograft mouse models
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