Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | 99.2% | 530.92 | 10 MG

Supplier:  Medchemexpress LLC 10MGHY15186A

Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3. It shows high selectivity for Akt1 over closely related kinases like PKA and p70S6K. In vivo, it is effective in xenograft models where Akt is activated due to genetic alterations, achieving tumor growth delay, stasis, or regression.

• Highly selective and ATP-competitive pan-Akt inhibitor
• Has IC50 values of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3
• Shows over 600-fold selectivity for Akt1 against PKA, and 100-fold against p70S6K
• Effective in xenograft models where Akt is activated
• Achieves tumor growth delay, stasis, or regression in vivo
• Well tolerated in immunocompromised mice at therapeutic doses
• Enhances tumor growth inhibition in combination therapies

Catalog No. 50-003-65659