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AdipoGen Ipragliflozin
Supplier: AdipoGen AGCR13546M010
Chemical. CAS 761423-87-4. Formula C21H21FO5S. MW 404.5. Ipragliflozin is an orally active, highly potent sodium glucose co-transporter 2 SGLT-2 inhibitor IC50 = 7.4nM, selective over SGLT-1, 3, 4, 5 and 6. SGLT-2 is one subtype of SGLTs found almost exclusively in the proximal tubules of nephronic components in kidneys, playing a key role in the re-uptake of glucose in the proximal tubule of the kidneys. Inhibition of SGLT-2 reduces blood glucose by blocking renal glucose reabsorption and thereby increasing urinary glucose excretion UGE. Anti-diabetic and anti-obesity agent. Shown to improve glycemic control and reduce body weight, furthermore, lowering hypoglycemic risk and abdominal symptoms. SGLT-2 inhibitors are likely to improve beta-cell function and insulin sensitivity and restore glucose homeostasis. Attenuates non-alcoholic steatohepatitis NASH development.
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