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Cayman Chemical IQ-1Sfree acId 10mg
SDP

Supplier:  Cayman Chemical 2985110 MG

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An inhibitor of NF-κB/AP-1 (IC50 = 2.3 µM in a reporter assay); inhibits the production of TNF-α and IL-6 production in human Mono-Mac-6 cells (IC50s = 1.3 and 3.8 µM, respectively) and isolated human PBMCs (IC50s = 2.6 and 5.6 µM, respectively), as well as NO production in murine J774-A.1 macrophages (IC50 = 3.1 µM); binds to JNKs (Kd = 0.24, 0.36, and 0.1 for JNK1-3), as well as CK1δ, PI3Kγ, and MKNK2 (Kds = 0.38, 0.47, and 0.92 µM, respectively)

Catalog No. 50-299-0554


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