Medchemexpress LLC IRAK4-IN-21 | 2170694-04-7 | C28H28FN7O2 | 10 MM 1 ML

Supplier:  Medchemexpress LLC HY15136310MM/1ML

IRAK4-IN-21 (compound 17) is an orally active, potent and selective IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively. It effectively inhibits IL-23 production (IC50=0.17 μM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis.

• Decreases the levels of IL-23 (in THP-1 and DC cells), IL-6 (in HUVEC cells), and MIP-1β (in human whole blood).
• Inhibits IL-23 levels in THP-1 and DC cells with IC50 of 0.17 and 0.51 μM, respectively.
• Inhibits IL-6 level in HUVEC cells with an IC50 of 0.20 μM.
• Inhibits MIP-1β level in human whole blood with an IC50 of 0.47 μM.
• Shows moderate efficacy in acute animal model studies for the inhibition of IL-6 production (in vivo).
• Oral administration of 75 mg/kg showed 54% inhibition of IL-6 in BALB/c mice.

Catalog No. 50-003-74193