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AdipoGen Irbesartan
SDP

Supplier:  AdipoGen CDXI0204M050

Encompass_Preferred

Chemical. CAS 138402-11-6. Formula C25H28N6O. MW 428.5. Irbesartan is an orally available angiotensin II type 1 AT1 receptor antagonist IC50 = 1.3 nM with antihypertensive activity. It binds to AT1 receptor with >5000 times higher affinity compared to AT2 receptor. Irbesartan also elicits selective peroxisome proliferator-activated receptor gamma PPARgamma-modulating activity and exhibits metabolic, anti-inflammatory and antioxidative properties. Irbesartan inhibits the receptor for advanced glycation end-products RAGE/high mobility group box 1 HMGB1 axis and maybe useful in prevention and treatment of various diseases. Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.

Catalog No. 50-256-0628


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