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AdipoGen Irbesartan
Supplier: AdipoGen CDXI0204M050
Chemical. CAS 138402-11-6. Formula C25H28N6O. MW 428.5. Irbesartan is an orally available angiotensin II type 1 AT1 receptor antagonist IC50 = 1.3 nM with antihypertensive activity. It binds to AT1 receptor with >5000 times higher affinity compared to AT2 receptor. Irbesartan also elicits selective peroxisome proliferator-activated receptor gamma PPARgamma-modulating activity and exhibits metabolic, anti-inflammatory and antioxidative properties. Irbesartan inhibits the receptor for advanced glycation end-products RAGE/high mobility group box 1 HMGB1 axis and maybe useful in prevention and treatment of various diseases. Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.
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