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Apexbio Technology LLC Irinotecan HCl Trihydrate(Synonyms: Campto, Camptosar, CPT-11, Irinotecan hydrochloride trihydrate, Irinotecan hydrochloride, Irinotecan HCl, Irinotecan, CPT 11 hydrochloride trihydrate), 10mM (in 1mL DMSO), CAS: 136572-09-3.
Supplier: Apexbio Technology LLC B22935.1
Irinotecan HCl Trihydrate (CAS 136572-09-3) also known as CPT-11 is a semisynthetic derivative of camptothecin designed to improve therapeutic efficacy while reducing toxicity It acts as a soluble prodrug which undergoes enzymatic cleavage by carboxylesterases in vivo to yield SN-38 a potent inhibitor of topoisomerase I CPT-11 exhibits cytotoxicity against leukemia (P388) cell lines with an IC50 of 3 4 M and demonstrates antitumor activity in vitro and in vivo against both drug-sensitive and multidrug-resistant tumor models It is FDA-approved for treating metastatic colorectal cancer following progression after fluorouracil-based therapies
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