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Medchemexpress LLC IRL-1620 | 142569-99-1 | 99.7% | 1820.95 | 1 MG
Supplier: Medchemexpress LLC HY164651MG
IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist. It is the most potent and specific ligand for the ETB receptor, with a Ki of 16 pM, showing 60 times more selectivity for the ETB receptor than ET-3. This compound is for research use only.
- Induces contractions of the guinea pig trachea
- Increases cytosolic Ca2+ in the vascular endothelium
- Relaxes norepinephrine-stimulated tone in rat aorta
- Improves acquisition and retention in the water maze task
- Enhances angiogenic and neurogenic remodeling
- Reduces cognitive impairment induced by Aβ in rats
- Enhances the number of blood vessels labeled with VEGF
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