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TARGETMOL CHEMICALS INC ISAVUCONAZONIUM SULFATE 25MG
Supplier: TARGETMOL CHEMICALS INC T393425MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51) which catalyzes the demethylation of lanosterol to yield ergosterol an important component of the fungal cell membrane. Isavuconazonium Sulfate is a prodrug of the triazole antifungal agent isavuconazole with broad-spectrum antifungal activity. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts the synthesis of the fungal cell membrane which decreases membrane integrity increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death. purity: 99%
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