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AdipoGen ISG15 (human) (rec.) (Rhodamine 110) (50 µg)
SDP

Supplier:  AdipoGen SBBPS0002C050

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ISG15 (human) (rec.) (Rhodamine 110) (50 µg), AdipoGen Life Sciences. Protein. Human ISG15 (aa1-157)conjugated at the C-terminus to a quenched Rhodamine 110 dye. Source: E. coli. Formulation: Liquid. In 50mM MES pH 6.0, 100mM sodium chloride, 10% glycerol. Purity: >97% (LCMS). ISG15 (Interferon Stimulated Gene, 15kDa) is a ubiquitin-like modifier which initiates innate immune response by activating RIG-I signaling, stimulating NK-cell proliferation, inhibiting viral budding and acting as an IFNgamma-inducing cytokine. ISG15 contains two tandem ubiquitin homology domains and is cross-reactive with alpha-Ubiquitin antibodies. Conjugation of ISG15 to a substrate protein occurs through a ubiquitin like cascade via an E1 (UBE1L), E2 (UbcH8/UBE2L6) and E3 (not yet discovered.) Deconjugation normally occurs via UBP43 (USP18), however there are several viral proteases that are able to hydrolyze ISG15 conjugates in order to evade immune response.

Catalog No. 50-148-9533


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