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Medchemexpress LLC Isoallolithocholic acid | 2276-93-9 | 99.8% | 1 ML
SDP

Catalog No. 5000407224
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Isoallolithocholic acid, a derivative of Lithocholic acid, functions as a T cell regulator by enhancing the differentiation of regulatory T cells (Tregs). It selectively modulates T cell differentiation, impacting Th17 cells without affecting Th1 or Th2 cell development. In vivo studies have shown its ability to increase Treg cells.

  • Reduces Th17 cell differentiation by approximately 50% at 20 μM.
  • Does not affect RORγt expression.
  • Does not influence differentiation of T cells into Th1 or Th2 cells.
  • Enhanced expression of FoxP3 is dependent on mitoROS.
  • Increases Treg cells in B6 mice in vivo (0.03% in diet for 7 days).
  • Significantly enhances Treg population when combined with 3-oxolithocholic acid in anti-CD3 treated mice.
  • Reduces the number of CD45.1+ T effector cells.

Catalog No. 50-004-07224 Supplier Medchemexpress LLC Supplier No. HYB0172A10MM/1ML
May include imposed supplier surcharges.
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Isoallolithocholic acid, a derivative of Lithocholic acid, functions as a T cell regulator by enhancing the differentiation of regulatory T cells (Tregs). It selectively modulates T cell differentiation, impacting Th17 cells without affecting Th1 or Th2 cell development. In vivo studies have shown its ability to increase Treg cells.

  • Reduces Th17 cell differentiation by approximately 50% at 20 μM.
  • Does not affect RORγt expression.
  • Does not influence differentiation of T cells into Th1 or Th2 cells.
  • Enhanced expression of FoxP3 is dependent on mitoROS.
  • Increases Treg cells in B6 mice in vivo (0.03% in diet for 7 days).
  • Significantly enhances Treg population when combined with 3-oxolithocholic acid in anti-CD3 treated mice.
  • Reduces the number of CD45.1+ T effector cells.

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