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Cayman Chemical Isoalntolacton 50mg
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Supplier:  Cayman Chemical 3383850 MG

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A topoisomerase II-a poison inhibits topoisomerase II-a by 78.9 at 20 UM selective for topoisomerase II-a over topoisomerase I providing 100 and 0 inhibition respectively at 100 UM inhibits proliferation of HCT15 T47D DU145 and HeLa cancer cells (IC50s 0.014 0.00267 0.072 and 2.46 UM respectively) induces apoptosis in T47D cells at 10 and 30 UM reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer at 12 mg/kg per day

Catalog No. 50-295-0103


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