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Medchemexpress LLC Isoangustone A | 129280-34-8 | 1 MILLIGRAM
Supplier: Medchemexpress LLC HYN40061MG
Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death.
- Suppresses proliferation and induces G1 phase cell cycle arrest in SK-MEL-28 cells.
- Decreases the abundance of G1 phase-related proteins mediated through Akt/GSK3β and MKK4/MKK7/JNKs signaling pathways.
- Suppresses PI3-K, MKK4, and MKK7 kinase activities by directly binding in an ATP-competitive manner.
- Induces autophagy in colorectal cancer cells by activating AMPK signaling.
- Inhibits mitochondrial respiration.
- Induces SW480 cells apoptosis.
- Suppresses mesangial fibrosis and inflammation in human renal mesangial cells.
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