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Cayman Chemical IsoguvacInhydrochlorIde 100mg
SDP

Supplier:  Cayman Chemical 33143100 MG

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A GABAA; binds to rat synaptic cortical membranes (Ki = 55 nM); activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively); inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM); inhibits potassium/low magnesium-induced seizures in rat pups; chronic administration improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of ASD at 2 mg/kg

Catalog No. 50-295-0312


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