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Medchemexpress LLC Isosilybin | 72581-71-6 | 482.44 | 50 MG
Supplier: Medchemexpress LLC HYN077950MG
Isosilybin is a flavonoid derived from Silybum marianum that functions as an inhibitor of CYP3A4 induction. It is intended for research use only.
- Inhibits PXR-mediated CYP3A4 induction with an IC50 of 74 μM.
- Acts as a stronger inhibitor of PXR-mediated CYP3A4 induction compared to silybin.
- Exhibits anti-prostate cancer activity through cell cycle arrest and apoptosis induction.
- Increases phosphorylation of Akt and Mdm2, associated with androgen receptor degradation.
- Enhances the formation of a complex between Akt, Mdm2, and AR.
- Can significantly activate PPARγ and causes transactivation of a PPARγ-dependent luciferase reporter.
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