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Medchemexpress LLC Isosilybin B | 142796-22-3 | 1 MG
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Supplier:  Medchemexpress LLC HYN70451MG

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Isosilybin B is a flavonolignan isolated from Silybum marianum that demonstrates anticancer activity, particularly against prostate cancer. Its mechanisms involve regulating cell cycle proteins and promoting apoptosis.

  • Regulates cell cycle-related proteins (cyclins, Cdk4, Cdk2, Cdc25A).
  • Activates caspases (caspase-9 and caspase-3) to promote apoptosis.
  • Reduces androgen receptor (AR) and prostate-specific antigen (PSA) levels.
  • Exhibits cytotoxicity in Huh-7 cells with an IC50 of 27 μM.
  • Induces G1 arrest and increased cell death in LNCaP and 22Rv1 prostate cancer cells.

Catalog No. 50-004-19005


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