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AdipoGen Isotretinoin (250 mg)
Supplier: AdipoGen AGCR13709M250
Chemical. CAS: 4759-48-2. Formula: C20H28O2. MW: 300.4. Vitamin A analog that inhibits cell proliferation and induces cell differentiation. It is converted in vivo into all-trans retinoic acid and has diverse biological activities. Anti-inflammatory agent used for severe acne treatment. Inhibits proliferation of primary human sebocytes by inducing cell-cycle arrest and inhibiting DNA synthesis. Amplifies production of neutrophil gelatinase-associated lipocalin (NGAL) in the skin, by inducing apoptosis in sebaceous gland cells, while exhibiting an antimicrobial effect on Propionibacterium acnes. Decreases the size and sebum output of the sebaceous glands. It also decreases triglyceride, stearyl ester and free fatty acid synthesis and modulates keratin expression in primary human sebocyte. Isotretinoin produces significant anti-inflammatory effects by inhibition of monocyte and neutrophil chemotaxis across intact biological barriers in vivo.
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