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Medchemexpress LLC Ispinesib | 336113-53-2 | 99.6% | C30H33ClN4O2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY50759100MG

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Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), exhibiting a Ki app of 1.7 nM.

  • Potent and highly specific inhibition of KSP.
  • Inhibits the growth of BT-474 and MDA-MB-468 cell lines.
  • Suppresses proliferation and induces apoptosis in prostate cancer cells.
  • Up-regulates genes for apoptosis and cell cycle arrest, while down-regulating genes for cell proliferation and survival.
  • Anti-proliferation and pro-apoptotic activities can be enhanced in combination with genistein.
  • Reduces tumor volume in mouse models bearing various breast cancer xenografts.

Catalog No. 50-003-58146


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