Isradipine, 98+%, Thermo Scientific Chemicals

Description

L-type calcium channel blocker

Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

Solubility
Soluble in DMSO

Notes
Protect from heat. Store away from oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 75695-93-1
• Molecular Formula: C19H21N3O5
• Molecular Weight (g/mol): 371.39
• MDL Number: MFCD00153820
• InChI Key: HMJIYCCIJYRONP-UHFFFAOYNA-N
• Synonym: isradipine, dynacirc, isradipin, lomir, isrodipine, prescal, dynacirc cr, esradin, clivoten, dynacrine
• PubChem CID: 3784
• IUPAC Name: 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• SMILES: COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C

• Color: Yellow
• Quantity: 50 mg
• Merck Index: 14,5240
• Solubility Information: Soluble in DMSO
• Formula Weight: 371.39
• Percent Purity: ≥98%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Isradipine

Safety and Handling

TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only