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Medchemexpress LLC Isrib (trans-isomer) | 1597403-47-8 | 99.49% | 451.34 | 50 MG
SDP

Supplier:  Medchemexpress LLC 50MGHY12495

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ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. It effectively reverses the effects of eIF2α phosphorylation and reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress. This trans-isomer is 100-fold more potent than cis-ISRIB, demonstrating stereospecific interaction with its cellular target.

  • Potently reverses eIF2α phosphorylation (IC50=5 nM)
  • Blocks eIF2α phosphorylation-induced stress granule (SG) formation
  • Increases long-term memory in rodents
  • Readily crosses the blood-brain barrier

Catalog No. 50-003-66147


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