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Medchemexpress LLC Isrib (trans-isomer) | 1597403-47-8 | MFCD27952932 | 99.5% | 451.34 g/mol | C22H24Cl2N2O4 | 5MG
SDP

Supplier:  Medchemexpress LLC HY124955MG

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ISRIB (trans-isomer) is a potent small-molecule inhibitor that reverses eIF2α phosphorylation and inhibits PERK signaling. It is used in cellular and in vivo research to modulate the integrated stress response and memory-related pathways.

  • Reverses eIF2α phosphorylation and inhibits PERK signaling (IC50 = 5 nM).
  • Trans stereoisomer with approximately 100-fold greater potency than the cis isomer.
  • High purity, 99.5% (HPLC), supplied as a solid, white to off-white powder.
  • Storage: powder stable at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent store at -80°C for long term.
  • Common applications include integrated stress response studies, cellular signaling assays, and in vivo memory research.

Catalog No. 50-002-37288


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