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Apexbio Technology LLC Istaroxime hydrochloride 374559-48-5 2mg
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Catalog No. 502240386
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Istaroxime hydrochloride (CAS 374559-48-5) also known as PST2744 is a small-molecule inhibitor of Na /K -ATPase with an IC50 of 0 43 0 15 M In vitro studies demonstrate that istaroxime selectively inhibits Na /K -ATPase activity in canine kidney preparations without significant interactions with unrelated receptors The compound enhances cellular contractility increasing inotropic response by up to 60% and augments atrial contractility in isolated guinea pig hearts across concentrations of 0 3 30 M Preclinical studies indicate that istaroxime has a safety profile superior to digoxin Clinically istaroxime is under investigation for its potential in treating acute heart failure by improving intracellular calcium cycling and cardiac contractility

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Catalog No. 50-224-0386 Supplier Apexbio Technology LLC Supplier No. A35082
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Istaroxime hydrochloride (CAS 374559-48-5) also known as PST2744 is a small-molecule inhibitor of Na /K -ATPase with an IC50 of 0 43 0 15 M In vitro studies demonstrate that istaroxime selectively inhibits Na /K -ATPase activity in canine kidney preparations without significant interactions with unrelated receptors The compound enhances cellular contractility increasing inotropic response by up to 60% and augments atrial contractility in isolated guinea pig hearts across concentrations of 0 3 30 M Preclinical studies indicate that istaroxime has a safety profile superior to digoxin Clinically istaroxime is under investigation for its potential in treating acute heart failure by improving intracellular calcium cycling and cardiac contractility

This item is not returnable. View return policy
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