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Apexbio Technology LLC Istaroxime hydrochloride 374559-48-5 2mg
Supplier: Apexbio Technology LLC A35082
Istaroxime hydrochloride (CAS 374559-48-5) also known as PST2744 is a small-molecule inhibitor of Na /K -ATPase with an IC50 of 0 43 0 15 M In vitro studies demonstrate that istaroxime selectively inhibits Na /K -ATPase activity in canine kidney preparations without significant interactions with unrelated receptors The compound enhances cellular contractility increasing inotropic response by up to 60% and augments atrial contractility in isolated guinea pig hearts across concentrations of 0 3 30 M Preclinical studies indicate that istaroxime has a safety profile superior to digoxin Clinically istaroxime is under investigation for its potential in treating acute heart failure by improving intracellular calcium cycling and cardiac contractility
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