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AdipoGen Isthmin-1 human ELISA Kit
Supplier: AdipoGen AG45B0032KI01
Colorimetric Sandwich ELISA Assay. Detects human Isthmin-1 in plasma and cell culture supernatant. It detects also mouse Isthmin-1 very conserved. Range 0.625 to 40ng/ml. Sensitivity 0.4 ng/ml. Samples Cell Culture Supernatant, Plasma. Isthmin-1 ISM1 was first identified as a gene expressed in the Xenopus midbrain-hindbrain organizer called the isthmus, with a proposed role during early brain development. Isthmin-1 encodes a predicted ~50-kDa protein containing a signal peptide, a thrombospondin domain and an adhesion-associated domain. Isthmin-1 is important for embryonic and postnatal development. Growing evidence has shown that aberrant expression of Isthmin-1 can also affect the biological behavior of cancer. The Ism1 gene is conserved in mice and humans. A recent study showed that Isthmin-1 is an adipokine that induces glucose uptake in human and mouse adipocytes.
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