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Medchemexpress LLC Istradefylline | 155270-99-8 | MFCD00928421 | 99.89% | 384.43 | 200 MG
Supplier: Medchemexpress LLC 200MGHY10888
Istradefylline is a potent, selective, and orally active antagonist of the adenosine A2A receptor, demonstrating a high affinity for this receptor in various experimental models, including those relevant to Parkinson's disease. It exhibits significantly greater affinity for the A2A receptor compared to the A1 receptor, making it a valuable tool for research into neurological conditions and adenosine signaling pathways.
- Highly potent and selective adenosine A2A receptor antagonist.
- Orally active in experimental models.
- Displays neuroprotective effects in Parkinson's disease models.
- Reverses drug-induced catalepsy and hypokinesia.
- Enhances antiparkinsonian activity when combined with dopamine agonists.
- Prevents astrogliosis in primary rat striatal astrocytes.
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