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Apexbio Technology LLC Istradefylline (KW-6002) 155270-99-8 25mg
Supplier: Apexbio Technology LLC A845425
Istradefylline (KW-6002 CAS nan) is a small-molecule antagonist targeting the adenosine A2A receptor (A2AR) It is designed to selectively inhibit A2AR thereby modulating the adenosine pathway and regulating neuronal activity Istradefylline exerts its biological activity primarily through antagonism of A2AR enhancing inhibitory signaling via GABAergic medium spiny neurons and modulating basal ganglia output In experimental Parkinson s disease models such as mouse MPTP-induced neurotoxicity istradefylline pretreatment has been observed to attenuate dopamine depletion in the striatum Based on these pharmacological properties istradefylline holds research potential in neuroprotective strategies and receptor-mediated pathway studies in neurodegenerative research
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