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Medchemexpress LLC Itacnosertib (hydrochloride) | 2409543-84-4 | 99.4% | 505.01 | 50 MG
Supplier: Medchemexpress LLC HY109179A10MM/1ML
Itacnosertib hydrochloride (TP-0184 hydrochloride) is an inhibitor for FLT3, ACVR1, and JAK2. It exhibits anti-leukemic activity and is intended for research use only. This compound has shown promising results in pre-clinical studies, demonstrating its potential in various biological applications.
- Inhibits FLT3, ACVR1 (ALK2), and JAK2
- Exhibits anti-leukemic activity
- Arrests cell cycle of MOLM-13, MOLM-14, and MV4-11 at G1/G0 phase
- Inhibits proliferation of acute myeloid leukemia (AML) cells
- Inhibits activation of FLT3 and ACVR1 downstream signaling pathways
- Shows antitumor activity in mouse xenograft models
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