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Medchemexpress LLC Itacnosertib hydrochloride | 2409543-84-4 | 99.4% | 505.01 | C26H29ClN8O | 5 MG
Supplier: Medchemexpress LLC HY109179A5MG
Itacnosertib hydrochloride is the hydrochloride salt of TP-0184, a small-molecule investigational inhibitor that potently targets ACVR1/ALK2 (reported IC50 ≈ 8 nM), shows activity against FLT3, and has markedly weaker activity versus JAK2 (reported IC50 ≈ 8,540 nM). It has demonstrated anti-leukemic activity in preclinical studies and is supplied for research use as a high-purity hydrochloride salt.
- Potent ACVR1/ALK2 inhibition (IC50 ≈ 8 nM).
- Activity against FLT3 with reported anti-leukemic effects.
- Markedly weaker JAK2 activity (IC50 ≈ 8,540 nM), indicating selectivity.
- Supplied as the hydrochloride salt for improved solubility.
- High reported purity (~99.4%) backed by certificate of analysis.
- Provided in small research pack sizes suitable for in vitro studies.
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