U-Blot Pan-Itaconyl-Cysteine Rabbit pAb is a Rabbit-derived polyclonal antibody that specifically recognizes Itaconyl-Cysteine a cysteine itaconylation modification at Cys(C) It shows reactivity with Species Independent Validated applications include WB IHC-P ICC/IF FC Recommended dilutions WB 11000 IHC-P 1100-1200 ICC/IF 1100-1200 FC 1100-1200 Purified by protein a Itaconyl-Cysteine (C(itacon)) is a novel metabolism-dependent post-translational modification occurring on cysteine residues of proteins This modification is mediated by itaconate a metabolite abundantly produced under immune activation and inflammatory conditions via covalent reaction with the thiol group of cysteine Itaconylation is widely involved in key biological processes including inflammatory signaling oxidative stress response innate immunity and metabolic reprogramming Supplied as 100 uL