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Apexbio Technology LLC ITF2357 (Givinostat) 732302-99-7 200mg
SDP

Catalog No. 5000063993
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ITF2357 (Givinostat CAS 732302-99-7) is a small molecule inhibitor targeting class I and II histone deacetylases (HDAC) It suppresses hematopoietic colony formation driven by JAK2V617F mutation in chronic myeloproliferative neoplasms Mechanistically ITF2357 induces apoptosis in multiple myeloma (MM) and acute myeloid leukemia (AML) by elevating p21 expression and simultaneously reducing anti-apoptotic proteins Bcl-2 and Mcl-1 Additionally ITF2357 diminishes inflammatory cytokines (IL-1 IL-6 TNF- and IFN- ) in peripheral blood mononuclear cells and inhibits production of IL-6 and VEGF in mesenchymal stromal cells reflecting potential therapeutic applications in cancer research and inflammation regulation

Catalog No. 50-000-63993 Supplier Apexbio Technology LLC Supplier No. A4093200
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ITF2357 (Givinostat CAS 732302-99-7) is a small molecule inhibitor targeting class I and II histone deacetylases (HDAC) It suppresses hematopoietic colony formation driven by JAK2V617F mutation in chronic myeloproliferative neoplasms Mechanistically ITF2357 induces apoptosis in multiple myeloma (MM) and acute myeloid leukemia (AML) by elevating p21 expression and simultaneously reducing anti-apoptotic proteins Bcl-2 and Mcl-1 Additionally ITF2357 diminishes inflammatory cytokines (IL-1 IL-6 TNF- and IFN- ) in peripheral blood mononuclear cells and inhibits production of IL-6 and VEGF in mesenchymal stromal cells reflecting potential therapeutic applications in cancer research and inflammation regulation

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