Invitrogen™ Human ITK, GST Tag Recombinant Protein

Catalog No.	Quantity
PV3875	10 μg
PR6992A	100 μg

Catalog No. PV3875 Supplier Invitrogen™ Supplier No. PV3875

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length, Recombinant, Cytoplasmic.

ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation. The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Itk (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Itk associates with CD28 and becomes activated subsequent to CD28 ligation.

Specifications

• Accession Number: Q08881
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 2mM DTT, 50% glycerol, 0.5mM EDTA, 0.02% Triton X-100, 150mM NaCl and no preservative; pH 7.5
• Gene ID (Entrez): 3702
• Molecular Weight (g/mol): 99.9 kDa
• Name: Human ITK, GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: EMT; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMT; kinase TLK; LPFS1; LYK; MGC126257; MGC126258; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; Tsk; Tyrosine-protein kinase ITK/TSK; tyrosine-protein kinase LYK
• Common Name: ITK
• Gene Symbol: ITK
• Kinase Family: TEC Kinase Family
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: Full length
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
• Kinase Group: Tyrosine Kinases
• Shipping Condition: Dry Ice
• System Compatibility: LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
• Target Entry: ITK
• Target Gene: IL2-inducible T-cell kinase
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Full Length, Recombinant, Cytoplasmic
• Form: Liquid
• Protein Subtype: Cytoplasmic Tyrosine Kinases
• Research Category: Signal Transduction
• Purity or Quality Grade: 90% by SDS-PAGE

Safety and Handling

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