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Apexbio Technology LLC Itraconazole(Synonyms: Sporanox, Orungal, R51211, Lozanoc, Triasporin, Fungitraxx, Onmel, Itranox, Sporal, Itrizole, Candistat), 10mM (in 1mL DMSO), CAS: 84625-61-6.
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Supplier:  Apexbio Technology LLC B21045.1

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Itraconazole (CAS 84625-61-6) is a triazole-based antifungal compound that functions primarily by inhibiting cytochrome P450 enzymes particularly CYP3A4 As both a substrate and inhibitor of CYP3A4 itraconazole undergoes oxidative metabolism into hydroxylated keto- and N-dealkylated derivatives all with demonstrated inhibitory activities comparable or superior to the parent compound In addition to antifungal effects itraconazole inhibits the hedgehog signaling pathway and angiogenesis Due to its affinity for mammalian CYP-P450 enzymes itraconazole is frequently employed in drug interaction studies assessing CYP3A-mediated metabolism

Catalog No. 50-000-60409


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