Apexbio Technology LLC Ivacaftor benzenesulfonate 1134822-09-5 25mg

Supplier:  Apexbio Technology LLC A351025

Ivacaftor benzenesulfonate (CAS 1134822-09-5) is a small molecule modulator of the cystic fibrosis transmembrane conductance regulator (CFTR) protein It acts as a potentiator enhancing CFTR channel open probability and facilitating chloride ion transport in cells carrying gating (G551D) or processing (F508del) mutations In vitro ivacaftor benzenesulfonate demonstrates IC50 values of 25 nM for F508del-CFTR and 100 nM for G551D-CFTR mutations and increases chloride secretion in human cystic fibrosis bronchial epithelial cells This compound is valuable in studies of CFTR function and in the investigation of therapeutic approaches for cystic fibrosis-related mutations

Catalog No. 50-000-93430