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Apexbio Technology LLC Ivacaftor (VX-770)(Synonyms: Kalydeco, VX-770, Ivacaftor, CFTR Potentiator VX-770, Ivacaftor VX-770), 100mg, CAS: 873054-44-5.
Supplier: Apexbio Technology LLC A5047100
Ivacaftor (VX-770 CAS 873054-44-5) is an orally bioavailable small molecule potentiator targeting the cystic fibrosis transmembrane conductance regulator (CFTR) Ivacaftor enhances CFTR-mediated chloride ion transport especially in cells expressing G551D- or F508del-CFTR mutations In vitro studies demonstrated that Ivacaftor in combination with forskolin significantly increased CFTR-dependent chloride secretion (EC50 100 nM in G551D- 25 nM in F508del-expressing cells) Similarly Ivacaftor reduced ENaC-mediated sodium reabsorption and increased airway surface liquid volume in human cystic fibrosis bronchial epithelial cells Ivacaftor is utilized in research to investigate CFTR function restoration and associated ion transport processes
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