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Medchemexpress LLC Ivarmacitinib | 1445987-21-2 | 99.6% | 414.48 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11272410MG

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Ivarmacitinib (SHR0302) is a potent and orally active inhibitor of all members of the JAK family, particularly JAK1. It demonstrates selectivity for JAK1, being >10-fold more selective for JAK2, 77-fold for JAK3, and 420-fold for Tyk2. Ivarmacitinib inhibits JAK1-STAT3 phosphorylation and promotes apoptosis in hepatic stellate cells, exhibiting anti-proliferative and anti-inflammatory properties.

  • Potent and orally active JAK family inhibitor.
  • Highly selective for JAK1.
  • Inhibits JAK1-STAT3 phosphorylation.
  • Induces apoptosis in hepatic stellate cells.
  • Possesses anti-proliferative effects.
  • Exhibits anti-inflammatory effects.

Catalog No. 50-004-37216


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