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Apexbio Technology LLC IWP-2 686770-61-6 10mg
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Supplier:  Apexbio Technology LLC A351210

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IWP-2 (CAS 686770-61-6) is a small molecule inhibitor targeting the Wnt/ -catenin signaling pathway through inhibition of Porcn a membrane-bound O-acyltransferase involved in palmitoylation and subsequent secretion of Wnt proteins In cellular assays IWP-2 inhibits Wnt pathway activation with an IC50 of approximately 27 nM Porcn overexpression reduces IWP-2 sensitivity confirming Porcn as the compound s molecular target In zebrafish models addition of IWP-2 did not suppress tail fin regeneration suggesting limited bioavailability in vivo Currently IWP-2 is utilized primarily for preclinical research on Wnt signaling in developmental biology and oncology

Catalog No. 50-000-61423


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