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AdipoGen IWR-1-endo
SDP

Supplier:  AdipoGen AGCR13581M005

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Chemical. CAS 1127442-82-3. Formula C25H19N3O3. MW 409.4. Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 TNKS1/PARP5a and Tankyrase-2 TNKS2/PARP5b inhibitor in vitro auto-PARsylation assay.

Catalog No. 50-256-2274


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