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Medchemexpress LLC Izmynd8-34 | 1358901-59-3 | 98.8% | 449.42 | 100 MG
SDP

Catalog No. 5000404757
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iZMYND8-34 is a ZMYND8 inhibitor with an IC50 of 0.66 μM. It inhibits the binding of H3K4me1-H3K14ac peptide to the ZMYND8 protein and blocks ZMYND8's histone recognition, also inhibiting neuroendocrine prostate cancer development.

  • Binds to recombinant ZMYND8-PBP with a dissociation constant (Kd) of 1.73 μM.
  • Significantly inhibits the growth of NE1.3 cells, TKO and ST88 organoids.
  • Extended mouse survival and reduced end-stage tumor volume in animal models.
  • Shifted tumor histology and eliminated NEPC cell populations.
  • Completely prevented metastatic spread to lymph nodes, lungs, and liver.
  • Inhibited LTL-331 PDX tumor growth and extended mouse survival in another animal model.
  • Reduced the percentage of CHGA+ NEPC cells and decreased Ki67+ proliferating cells.

Catalog No. 50-004-04757 Supplier Medchemexpress LLC Supplier No. HY403538100MG
May include imposed supplier surcharges.
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iZMYND8-34 is a ZMYND8 inhibitor with an IC50 of 0.66 μM. It inhibits the binding of H3K4me1-H3K14ac peptide to the ZMYND8 protein and blocks ZMYND8's histone recognition, also inhibiting neuroendocrine prostate cancer development.

  • Binds to recombinant ZMYND8-PBP with a dissociation constant (Kd) of 1.73 μM.
  • Significantly inhibits the growth of NE1.3 cells, TKO and ST88 organoids.
  • Extended mouse survival and reduced end-stage tumor volume in animal models.
  • Shifted tumor histology and eliminated NEPC cell populations.
  • Completely prevented metastatic spread to lymph nodes, lungs, and liver.
  • Inhibited LTL-331 PDX tumor growth and extended mouse survival in another animal model.
  • Reduced the percentage of CHGA+ NEPC cells and decreased Ki67+ proliferating cells.

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