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AdipoGen izTRAIL Soluble h rec
Supplier: AdipoGen AG40B0069C010
Protein. The extracellular domain of human TRAIL aa 95-281 is fused at the N-terminus to an isoleucine zipper motif. Source E. coli. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20. Binds to human TRAIL receptors 1-4 TRAIL-R1 to TRAIL-R4 izTRAIL does not interact with the apoptosis-inducing mouse TRAIL receptor TRAIL-R. Purity >95% SDS-PAGE. izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper iz motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL shTRAIL. Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL.
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