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Medchemexpress LLC J147 | 1146963-51-0 | 99.5% | 350.34 | 100 MG
Supplier: Medchemexpress LLC HY13779100MG
(E/Z)-J147 is an exceptionally potent, orally active neuroprotective agent that enhances cognitive function. It can easily cross the blood-brain barrier (BBB) and shows potential for the study of Alzheimer's disease (AD). It inhibits monoamine oxidase B (MAO B) and the dopamine transporter.
- Neuroprotection and cognitive enhancement
- Readily passes the blood-brain barrier (BBB)
- Inhibits monoamine oxidase B (MAO B) with an EC50 value of 1.88 μM and the dopamine transporter with an EC50 value of 0.649 μM
- Shows potential for the study of Alzheimer's disease (AD)
- Promotes HT22 and primary cell survival in a dose-dependent manner, with an EC50 value range of 0.06-0.115 μM
- Enhances memory and dendritic spine number in old mice when administered in their diet at 200 ppm for 6 months
- Half-life (t1/2) in plasma is 1.5 hours and in the brain is 2.5 hours after a single oral dose of 20 mg/kg
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